Putting the brakes on the unfolded protein response

Putting the brakes on the unfolded protein response

The unfolded protein response is an ancient cellular pathway for rapidly responding to endoplasmic reticulum stress. Two studies in this issue (Rubio et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201007077 and Chawla et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201008071) provide insight into how the unfolded protein response is tamped down to restore normal endoplasmic reticulum function. Althoug...

Putting the brakes on chondrosarcoma

Primary cartilaginous tumors often arise from endochondral ossification, range from benign endochondroma and osteochondroma to malignant chondrosarcoma, and are notoriously resistant to chemotherapy or radiation. This urges development of novel therapeutic approaches particularly in chondrosarcoma, which is a terminal disease in more than 90% of unresectable cases [1]. Now research of Zhou and ...

Putting the Brakes on Fear

The extinction of fear is believed to involve inhibitory processes in the amygdala. In this issue of Neuron, Trouche et al. (2013) show that basal amygdala neurons activated by fear conditioning are silenced by local inhibitory interneurons after extinction.

Putting the brakes on cylindromatosis?

In patients with familial cylindromatosis, or “turban tumors,” numerous benign skin adnexal tumors develop, principally on the head and neck (Fig. 1). This rare disorder is caused by a mutation of the CYLD gene and has a variable penetrance. Thanks to three recent studies 2-4 and, in particular, to the work of Brummelkamp and colleagues, 2 we now have a more accurate conception of the disease p...

Putting the brakes on drive-through deliveries.